JCI insight 4 , e132975 (2019)
173,320 Cell death mechanisms, including apoptosis, ferroptosis, and necroptosis across different cell types, are interconnected with oxidative and inflammatory signaling cascades (e.g., NF-B, PI3K/Akt inhibition), many of which are initiated or amplified by GC exposure and vascular hypoperfusion, ultimately leading to reduced bone mass and microcirculatory dysfunction
Chace DH, Pons R, Chiriboga CA, McMahon DJ, Tein I, Naylor EW, et al
Lower doses during initial weeks cost less, while maintenance doses at higher levels increase ongoing expenses
These benefits were further supported by the results of the SUMMIT trial, which investigated tirzepatide, a dual GLP-1/glucose-dependent insulinotropic polypeptide receptor agonist, in patients with HFpEF with or without T2D
Sjgren syndrome A connective tissue disorder characterized by the involvement of exocrine glands, causing dry eyes and/or mouth, as well as systemic symptoms