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An in vitro study using GnRH neurons of adult male mice demonstrated that both GLP-1 and Ex4 might excite GnRH neurons, either directly or indirectly by modulating the nitric oxide (NO) and endocannabinoid pathways that control the presynaptic excitatory GABA-ergic inputs to GnRH neurons [36]
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doi:10.1056/NEJMoa1607141 43
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For example, the mitochondria in their skeletal muscle have become smaller and shorter, while those of white adipose tissue (WAT) are small and elongated, with an irregular crest, and the larger the adipocytes, the less mitochondria are present (7476)
Most patients experience appetite suppression within 1 to 2 weeks
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