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If so, what magnitude of improvement in cardiovascular outcomes will be necessary to move the needle

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This common question arises from confusion with earlier diabetes medications

The focus should be on creating a sustainable energy deficit that promotes gradual weight loss (typically 0.5-1 kg per week) whilst preserving lean body mass and ensuring adequate nutrition

Itching (pruritus) at the injection site is a recognised local adverse reaction associated with tirzepatide and other injectable medications

Meaningful weight loss typically begins at the 5mg dose level and accelerates at higher doses