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References 1 American Diabetes A

Under homeostatic conditions, transient activation of NRF2 is cytoprotective, allowing for adaptation to various cell intrinsic (i.e., reactive oxygen species (ROS) generated by mitochondrial function) and extrinsic (i.e., xenobiotic) stressors (Kensler et al, 2007

Loading phase (deficiency): 1000 mcg IM or subQ daily or every other day for 1 to 2 weeks Maintenance: 1000 mcg monthly is a standard maintenance dose for conditions like pernicious anemia Wellness protocols: may use lower doses weekly, though this is less established clinically In ml: cyanocobalamin is typically supplied at 1000 mcg/ml, so a 1000 mcg dose equals 1 ml

The active ingredient in Ozempic, semaglutide, is also approved to treat obesity under the name Wegovy

Mechanical Load and GLP-1 Exercise Skeletal muscle depends on mechanical stress for its growth and maintenance a principle known as mechanotransduction

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