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Patients ( n = 49) were mostly female (73%), average age 54 years old, with relapsing disease (78%) and an average starting body mass index (BMI) of 39.7 kg/m 2 (range 25.9, 58.9 kg/m 2
The superficial fat pads and deep fat pads in the face also reduce, and this tissue is crucial for a youthful, lifted look
Hierarchy of Evidence: Level D (Pre-clinical animal models)
These free radicals can cause dark spots, wrinkles, and sagging by breaking down collagen and elastin fibers
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