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These findings support ongoing investigation into age-related cellular signaling

210 Acetyl-CoA then starts the TCA cycle, where NAD + serves as a coenzyme for three rate-limiting enzymes, -ketoglutarate dehydrogenase (KGDH), isocitrate dehydrogenase 3 (IDH3) and malate dehydrogenase (MDH2), to generate NADH