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The progression of LN to ESKD is influenced by various factors, including the initial nephron number (determined at birth), episodes of nephron loss (during LN flare), and the rate of nephron loss beyond physiological aging (ongoing inflammation due to LN) or in some cases concomitant uncontrolled diabetes mellitus, and/or hypertension ( Effective management of LN during pregnancy is pivotal to minimizing maternal and fetal risks

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