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One severe consequence of oxidative stress, leading to erythrocyte stiffness and morphological changes, is eryptosis [208, 230, 232, 375]

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Most people get enough from diet, but older adults, vegans, and those with certain medical conditions may require supplementation

[14] [15] You should temporarily stop taking metformin during acute illnesses that may cause dehydration (such as severe vomiting, diarrhoea, or fever), before certain procedures, or if you have heavy alcohol intake ('sick-day rules')

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doi:10.1074/jbc.M806122200