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Despite this rapid clearance, SFN and its conjugates effectively distribute to various tissues, including the prostate, lung, and bladder, where they can accumulate at concentrations sufficient to exert biological effects, as demonstrated in both rodent models and human tissue biopsies (47, 48)

However, in cRPMI in the presence of 10M of BAY 43-9006, no significant increase in PS exposure was observed

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Data are expressed as mean SEM