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BBB and BSCB disruption facilitate CNS infiltration of immune cells, including T cells, macrophages, and neutrophils, culminating in multifocal demyelination and neurodegeneration [143]
The more recent STEP UP trial tested a higher dose of 7.2 mg and showed average weight loss of 20.7% at 72 weeks
Most GLP-1 RA agents are administered via subcutaneous (SC) injection
During illness, your needs increase due to: Fever can increase insensible fluid losses and may increase fluid needs (often estimated around 10% per 1C) Respiratory symptoms causing moisture loss through breathing Reduced thirst sensation from GLP-1 effects Potential vomiting or diarrhea Adequate hydration during illness helps thin mucus secretions, supports immune function, maintains blood pressure, and prevents medication-related complications
It also has antibacterial properties that can reduce the bacteria producing hydrogen sulfide
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"Carnitine levels in epileptic children." J Child Neurol 1998;13:546-9
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