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Research from the SURPASS and SURMOUNT clinical trial programs has consistently shown this dual mechanism translates into superior clinical outcomes across nearly every measured endpoint

The fatty acid acylation of cagrilintide enables albumin binding in circulation, reducing renal clearance and extending the elimination half-life to support once-weekly dosing

It is also worth considering whether nutritional deficiencies which can develop during periods of significant dietary restriction may contribute to cold sensations

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GIP is a second incretin hormone

Understanding that this is a hormonal intervention, rather than just an appetite suppressant, helps patients view it as a tool to reset their metabolic signals