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Managing combined side effects Expect amplified GI effects: Both peptides slow gastric emptying Synergistic nausea (not just additive) Constipation very common Weeks 9-16 most challenging Nausea management protocol: Prevention from day 1 (ginger, small meals) Prescription anti-nausea (Zofran) essential Liquid nutrition if needed Slower titration if poorly tolerated Constipation prevention: 80-100 oz water daily Fiber 25-30g daily Magnesium citrate 300-500mg nightly MiraLAX as needed Nutrition maintenance: Protein shakes 2-3 daily (30-40g each) Target 60-80g protein minimum Multivitamin daily B12 supplementation When to reduce doses: Severe persistent nausea despite management Unable to maintain adequate nutrition Vomiting frequently Quality of life severely impacted See our common peptide mistakes beginners make to avoid errors
This is where antioxidants like glutathione come into play
10.1093/molbev/msp259 42 GreenA
How Long Does It Take to Improve Glutathione Levels
Unlike many traditional sleep aids, DSIP does not appear to significantly suppress REM sleep, which may help preserve essential cognitive and emotional processing
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