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Most of these oxygen metabolites are free radicals (H 2 O 2 is a non-radical ROS, but can easily be converted to free radicals), which have one or more unpaired electrons making them highly reactive (Reference Halliwell and Gutteridge44)
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The above phenomenon can be explained by the fact that the down-regulation of MITF expression will cause the down-regulation of TYR, TRP-1 and TRP-2, thereby inhibiting the synthesis of melanin, so the lower MITF expression will cause white plaques in patients with vitiligo
View source Gail A Greendale, Barbara Sternfeld, MeiHua Huang, Weijuan Han, Carrie Karvonen-Gutierrez, Kristine Ruppert, et al
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