Several mechanisms overlap
He L, Wu J, Tang W, Zhou X, Lin Q, Luo F, Yin Y, Li T (2018) Prevention of oxidative stress by alpha-ketoglutarate via activation of CAR signaling and modulation of the expression of key antioxidant-associated targets in vivo and in vitro
This double-blind placebo-controlled study was performed between May 2011 and October 2016 at Nova Southeastern University (Fort Lauderdale, FL, USA) at three locations: The Mailman Segal Center (informed consent and behavioral assessments: visits 1, 3, 4, 5, 6, and 7), Nova Southeastern University Clinic (pediatric visits 2 and 8, including blood sampling), and the blood samples were quantified at the College of Pharmacy
3 , eaar6676 (2018)
More recently, the synergistic therapeutic effect of combined GLP-1R and farnesoid-X receptor agonism on features of NASH in mice was reported 16
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