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They can cause significant muscle loss along with fat loss, which some research suggests may be as high as 30-40% of total weight lost
Francesco Puppi, recent podium finisher of the Western States 100, wrote a thoughtful piece about the state of drug testing in ultras following the high profile test failure of Joyline Chepngeno in 2025
While GLP-1s like Wegovy and Zepbound are first thought of when considering weight loss medications, there are other alternatives
Under physiological circumstances, low concentrations of ammonia are detectable
Instead, her biggest challenge was fatigue in the early weeks
It's that it's less likely to work against your efforts than some alternatives
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