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The most commonly reported side effects in Phase 2 trials are gastrointestinal: nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation

This represents a gap in the evidence base that researchers should acknowledge when making decisions about protocol adoption

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The GP can arrange initial investigations, including semen analysis, to evaluate sperm parameters such as volume, concentration, motility, and morphology

GH treatment consistently reduced fat mass and increased lean body mass

Notably, no cases of clinically significant hypoglycemia, medullary thyroid cancer, or C-cell hyperplasia were reported in published trial data