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however, this effect is less than the protelysis achieved by the PAI-mediated pathway (2)

Lys105 is a GSH and enzyme activator in the GSSCys assay In a first set of experiments, we analysed the effects of the Lys105 replacements on the steady-state kinetics at variable GSSCys and GSH concentrations

By balancing enthusiasm for emerging data with clear communication, clinicians can support patients effectively without overpromising outcomes