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Yet another compound, Honokiol (HKL), has been shown to protect against doxorubicin-induced cardiotoxicity by activating SIRT3, which helps reduce ROS production, prevent mitochondrial fragmentation, and promote mitochondrial fusion 187
Do not do this without laboratory confirmation
We conduct GSA with Partial Rank Correlation Coefficient (PRCC), which is a global method where all input factors (model parameters and/or initial conditions) are varied simultaneously using latin hypercube sampling
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The Phase 3 program (TRIUMPH) is ongoing in obesity, obstructive sleep apnea, and knee osteoarthritis indications
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