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Research has used MT-1 to characterise these melanin-independent photoprotection mechanisms and establishing that MC1R activation provides a layer of cellular UV protection through DNA repair enhancement and oxidative stress reduction thats distinct from and additive to the physical UV-screening function of melanin pigmentation

Comp Biochem Physiol C Toxicol Pharmacol (2006) 142:2319

Itoh H, Tanaka M

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