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Unlike platinum-induced mitochondrial dysfunction, vincristine may alter mitochondrial Ca 2+ signal transduction [5, 6] and promote signal expression in the process of inducing oxidative damage (including NOX1, NOX2 and iNOS), leading to oxidative stress of sciatic nerve tissue, and antioxidants such as HO-1 and NQO-1 are highly decreased [28]

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Of course in assessing other underlying triggers, we might want to test Lyme and co-infections IgeneX Lyme/Co-infection panels