Riboflavin, in the form of flavin adenine dinucleotide (FAD), is a required cofactor for glutathione reductase
It pushes it underground, where there's no pharmacist, no quality standard, and no way to build the very evidence everyone agrees is missing
Hunt A, Schnknecht P, Henze M, Seidl U, Haberkorn U, Schrder J
10.1016/j.chembiol.2003.10.003 31 MatsuiJ.HaqueA.HussD.MessanaE.AlosiJ.RobersonD.et al
So, one would hope that putting amino acids back will help collagen and elastin production
Chronic sleep deprivation can lead to lower baseline levels of glutathione, making supplementation even more vital