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Subcutaneous injection bypasses first-pass hepatic metabolism and delivers near 100% bioavailability, which is why all published rodent studies use injection rather than oral dosing

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Additional studies have proposed that melanocortin-based signaling may interact with hypothalamic pituitary adrenal axis activity and sympathetic outflow , contributing to coordinated systemic adaptations during hemorrhagic stress [16,17]

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Patents 4,698,360 5,720,956 and 6,372,266.