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The clinical trials showed steady weight loss progression through 68 weeks, with the most rapid loss occurring between weeks 8 and 32
What they do not have is a body of controlled evidence showing that injecting them causes clinically significant weight loss independent of diet, exercise, and the rest of a supervised program
(PubMed) Lajous M, Lazcano-Ponce E, Hernandez-Avila M, Willett W, Romieu I