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Based on the results of the MF profile computation, it can be concluded that the changed residues of the mGLP1-DARPin-1 and mGLP1-DARPin-2 fusion proteins are more stable than those of the native protein

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Three amino acid-altering GIP receptor variants (R190Q, E288G, and E354Q) are all associated with lower bone mineral density, and in postmenopausal women followed for 10 years, who were homozygous carriers of the E354Q variant, showed a higher risk of non-vertebral fractures (99, 101)

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Nausea and GI discomfort are more common when switching from Semaglutide (Wegovy) to Tirzepatide (Mounjaro), than the other way around