Semaglutide improves insulin sensitivity at the cellular level, allowing the pancreas to produce less insulin overall and restoring more normal hormonal signaling
Tirzepatide (which activates both GLP-1 and GIP receptors) has comparable headache rates to semaglutide in clinical trials
The provider reviews your medical history, current medications, contraindications, prior GLP-1 or GLP-1/GIP experience if any, and goals
Both Drs
Physiol Behav 283:114622 Besheer J, Hodge CW (2005) Pharmacological and anatomical evidence for an interaction between mGluR5-and GABAA 1-containing receptors in the discriminative stimulus effects of ethanol
The percentage of participants who had weight reduction of 5% or more was 85% (95% CI, 82 to 89), 89% (95% CI, 86 to 92), and 91% (95% CI, 88 to 94) with 5 mg, 10 mg, and 15 mg of tirzepatide, respectively, and 35% (95% CI, 30 to 39) with placebo