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For the separate analysis of results from the investigator-initiated study and the Phase I trial, the database was locked and loaded into SAS version 9.4 (Statistical Analysis Software

Hesperidin treatment improved endothelial function, suggesting this may be one important mechanism behind its benefit to the cardiovascular system

Compared with the control group, study participants who supplemented with taurine had a significant improvement in the primary outcome of reducing risk of metabolic syndrome, demonstrated by the following weighted mean changes: systolic blood pressure - 4 mm Hg diastolic blood pressure -1.5 mm Hg triglycerides -18.3 mg/dL fasting blood glucose -5.9 mg/dL There were also significant improvements in secondary outcomes as shown by the following weighted mean changes: LDL cholesterol - 6.5 mg/dL total cholesterol - 8.3 mg/dL fasting insulin -1.52 IU/L HOMA-IR (calculation of insulin resistance) - 0.7 There was no significant effect on HDL, body weight, and BMI

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Vitamin B12 deficiency isn't very common in the US, as people who don't eat enough animal products can still get vitamin B12 from supplements or fortified food sources

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