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Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine redness, swelling, the classic wheal. It is confirmed for SS-31, which activates the receptor well below its injection concentration

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Chapter 6 Diseases of the nervous system (G00-G99) The Excludes1 note that excluded codes in category H46 Optic neuritis from being reported with code G36.0 Neuromyelitis optica [Devic] was changed to an Excludes2 note