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Theres a reported 40-50% reduction of opioid and alcohol intoxication in people with a history of related disorders and there are phase 2 trials showing reductions in alcohol use and opioid cravings

Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism

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The lack of a difference in thyroid indices is consistent with previous findings, which suggest that L-carnitine has a peripheral action, rather than directly inhibiting the thyroid gland or influencing hypothalamicpituitary feedback

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Am J Physiol Gastrointest Liver Physiol 292: G1474-1482, 2007