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The mechanism is likely related to reduced caloric intake and metabolic adjustment rather than a direct drug effect

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For weight loss (Wegovy dosing schedule): 0.25 mg for four weeks, then 0.5 mg for four weeks, then 1 mg for four weeks, then 1.7 mg for four weeks, then 2.4 mg as the maintenance dose

Estrogen, Body Composition, and Fat Distribution GLP-1 medications dont directly alter estrogen levels, but weight loss achieved through GLP-1 therapy can have indirect effects on estrogen metabolism that are worth understanding

In patients with T2DM and CKD, SGLT2 inhibitors provide the most consistent renal protection, while GLP-1 receptor agonists effects are more variable

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