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The sudden increase in tissue pressure will force PPC molecules to flow backward along the injection track to the dermis, causing local chemical skin burns

a recent safety analysis found no anaphylaxis in hundreds of patients receiving high-dose IV thiamine, suggesting the risk is very low in practice

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FAQ Allison Buttarazzi, MD Medical Reviewer Allison Buttarazzi, MD, is board-certified in internal medicine and lifestyle medicine, and is a certified health and well-being coach

Accessed August 27, 2025

Scientific references The following are independent, peer-reviewed publications provided for reference