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While not classified as a controlled substance, it is regulated differently for research, therapeutic, and athletic contexts

The STEP 1 trial extension showed that participants regained two-thirds of their prior weight loss within one year of stopping

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High-resolution structural images of retatrutide bound to each of the three receptors, published in 2024, confirmed that one peptide can dock into three different receptor sites, providing the physical basis for the triple-receptor approach [3]