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In addition, other antioxidant systemsincluding GSH, thioredoxin (Trx), and peroxiredoxinsare highly active in CRC cells and collectively reinforce their defense against oxidative stress [34, 37, 38]
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This work was supported by the National Natural Science Foundation of China (U23A20501, 82404816), the key research and development plan projects of Heilongjiang Province (2022ZX02C04), the Guangdong Basic and Applied Basic Research Found Project (2023A1515110703), the Traditional Chinese Medicine Bureau Of Guangdong Province (20254061), the State Key Laboratory of Dampness Syndrome of Chinese Medicine (SZ2021ZZ49, SZ2022KF16), the Second Affiliated Hospital of Guangzhou University of Chinese Medicine(YN2024GZRPY017)
The ensuing mechanistic study revealed that ebselen protected cells and mice models by lowering radiation-induced ROS production, followed by inhibition of lipid peroxidation, protein carbonylation, DNA damage, and ultimately apoptosis
Early research suggests that taking L-carnitine can increase body mass index (BMI) and improve lean body mass in people with cancer and wasting syndrome
