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This complete absence of tolerability-driven discontinuations represents a remarkable safety finding and indicates that even when mild side effects occurred, they were sufficiently manageable that participants chose to continue treatment

Cons Requires a needle

in this form it is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine (a reaction which also requires folate)

Every intervention has trade-offs

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B12 levels can become low as a result of inadequate nutrition, decreased absorption of this vitamin in the intestines, stomach problems, infections or cancer