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Effects of Intensive Glycemic Control on Serum Levels of Insulin-Like Growth Factor-I and Dehydroepiandrosterone Sulfate in Type 2 Diabetes Mellitus

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In murine studies, deletion of the IGF-1R in skeletal muscle resulted in glucose intolerance issues ultimately leading to T2D at an early age, because, although they express insulin receptors, they cannot form hybrid or IGF-1 receptors [162]

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