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Rectal bleeding beyond minor streaking from hemorrhoids, particularly if dark or tarry stools are present, necessitates investigation to exclude gastrointestinal pathology

For most people, the initial adjustment period represents the highest-risk window, and it passes relatively quickly with proper management

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12 Overall, melanotic macules tend to be small ( 60 years), sex (male), and regional or distant metastasis, also are predictive of poor prognosis

this inflammation further depletes glutathione, which in turn prevents the liver from clearing the histamine, leading to even more mast cell reactivity