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Although the contribution of an excessive intake of methionine has not been clinically proven, folate deficiency (associated or not with the thermolabile mutation of MTHFR) and vitamin B 6 deficiency (perhaps associated with heterozygosity for CBS deficiency or with methionine excess) would be strongly involved in the incidence of cardiovascular disease associated with moderate hyperhomocysteinemia

Muftuoglu M, Andreeff M

Rasinger JD, Lundebye A, Penglase S, Ellingsen S, Amlund H (2017) Methylmercury induced neurotoxicity and the influence of selenium in the brains of adult zebrafish ( Danio rerio )

S2CID 3190634

Lancet 388:7385 Miller MS, Allen P, Brentnall TA et al (2016) Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report

Une supplmentation peut alors tre envisage sous diffrentes formes : par voie intraveineuse, topique, inhalation, complment alimentation oral, capsule ou encore liquide