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Oral semaglutide (Rybelsus) requires special consideration, as it must also be taken on an empty stomach and can increase thyroxine exposure when coadministered with levothyroxine, potentially necessitating dose adjustments and careful TSH monitoring
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Both factors can cause structural changes at the molecular level, making the peptide less reliable for use in controlled experiments
Squamous cell carcinoma of the esophagus
However, other side effects are way more concerning, such as in rare cases: gastroparesis (stomach paralysis), intestinal obstructions, gallbladder and pancreatic diseases
Consequently, therapeutic strategies that either inhibit or activate glucagon are being actively researched in clinical settings [104]
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