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Renal impairment reduces B12 excretion, leading to accumulation
With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels
Centered from the "inside" - "outside"
Since B12 is a water-soluble vitamin, excess amounts are typically eliminated through urine
Plasma B-vitamins and one-carbon metabolites and the risk of breast cancer in younger women
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