Two inconvenient truths: 1
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Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders
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Similarly, individuals with more severe insulin resistance may require longer to achieve optimal glycaemic control
These risk differences might be explained by additional mechanisms beyond the actions of GLP-1 RAs on vasculature, including the chronotropic effects of GLP-1 RAs which may blunt cardiac protection (Garg et al., 2019)