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Age (Dordr.) 38 , 26 (2016)
Neither approach is particularly helpful
Milder DA, Milder TY, Liang SS, et al
There is a further complication
This set included proteins previously established as containing hyper-reactive 35,36 or commonly liganded 37 cysteine residues (Supplementary Table 4)
In conclusion, while clinical translation is constrained by delivery, toxicity, and pharmacokinetic hurdles, ferritin-targeted approaches offer a novel and mechanistically rational avenue for treating aggressive brain cancers, warranting further preclinical optimization and early-phase clinical investigation
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