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Several reviews of the literature have described pathways that are potential targets of lipoic acid in various models and under different experimental conditions (49-52)

The assessment of placebo groups in randomized controlled trials for melasma allows for measuring the efficacy of broad-spectrum tinted sunscreens, accounting for a 1020% melasma area and severity index (MASI) reduction in 8 weeks [19]

Within cells, creatine is phosphorylated by creatine kinases (CK

intracellular half-life is prolonged because of lysosomal release and cytosolic resequestration, creating a depot effect that supports monthly maintenance dosing for chronic deficiencies

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