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Under cysteine deprivation, the ATF4-dependent ISR upregulates CHAC1 to sustain mitochondrial respiration via GSH catabolism

Glutathione supplement benefits: Taking oral supplements or precursor amino acids may help restore depleted levels and has been shown to support insulin sensitivity

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While these responses are adaptive in the short term, prolonged exposure to high cortisol levels and chronic stress can lead to maladaptive outcomes such as immunosuppression, impaired growth, altered behaviour, and oxidative damage, leading to increased disease susceptibility and reduced performance [19, 83]