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In aesthetic medicine, it is increasingly used: After microneedling procedures to accelerate recovery and enhance collagen induction Post laser resurfacing to support skin barrier restoration and reduce inflammation After chemical peels to minimize downtime and support reepithelialization In post-surgical recovery protocols to support soft tissue healing Citation: Pickart L, Vasquez-Soltero JM, Margolina A

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Phase 2 Trial Design Participants: 338 adults with obesity (BMI 30) or overweight with comorbidities (BMI 27), without diabetes Duration: 48 weeks Dosing groups: Placebo, 1mg, 4mg, 8mg, or 12mg weekly (with gradual dose escalation over 20-24 weeks) Primary endpoint: Percentage change in body weight from baseline Beyond Weight Loss: Metabolic Improvements Beyond weight loss, the 12mg dose also improved several cardiometabolic markers: Blood pressure: Systolic BP decreased by 7.4 mmHg (clinically significant reduction) Lipids: Triglycerides fell 30%, HDL cholesterol increased 8% Glucose control: HbA1c decreased 0.4% even in participants without diabetes Liver health: Markers of fatty liver disease (ALT, AST) improved significantly Inflammation: C-reactive protein (CRP) decreased, indicating reduced systemic inflammation What this means: Retatrutide appears to improve the metabolic dysfunction behind obesity-related diseases, not just the weight itself

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Although these findings have generated considerable interest, most of the available evidence comes from laboratory and animal studies rather than large human clinical trials