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Regarding protein expression, hepatic protein expression of GPx1/2 was observed to be reduced in MASLD rats as compared to controls (Li et al

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In human tissues, it is estimated that levels may drop from peak amounts by 50% within 24 hours post-administration

Rosuvastatin Potency: Very high-intensity statin LDL reduction: 2040 mg LDL by 50% Uses: Severe hypercholesterolemia High-risk cardiovascular patients Familial hypercholesterolemia Pharmacokinetics: Minimal hepatic metabolism Less CYP450 interaction Dose: 540 mg once daily Advantages: Strong LDL lowering Fewer drug interactions Atorvastatin Potency: High-intensity statin LDL reduction: 4080 mg LDL by 50% Uses: Dyslipidemia Secondary prevention of cardiovascular disease Post-MI and stroke prevention Pharmacokinetics: Metabolized by CYP3A4 Dose: 1080 mg once daily Advantages: Extensive evidence base Effective at lowering triglycerides Common Side Effects (Both) Myalgia / myopathy Elevated liver enzymes Rare: rhabdomyolysis Contraindications Active liver disease Pregnancy and breastfeeding Monitoring Baseline liver function tests Lipid profile after 412 weeks CK levels if muscle symptoms occur Rosuvastatin = more potent, fewer drug interactions Atorvastatin = CYP3A4 metabolism, more interactions Both reduce LDL and cardiovascular events significantly To view or add a comment, sign in 39,930 followers

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