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For the treatment regimen estimand, all tirzepatide doses were associated with numerically higher odds of participants with prediabetes achieving reversal versus liraglutide and semaglutide (Supplementary Material Table S8), although the higher proportion of patients with prediabetes achieving reversal in the placebo arm of SURMOUNT-1 compared with SCALE and STEP 1 suggests that the relative efficacy of tirzepatide versus liraglutide and semaglutide may be underestimated (Supplementary Material Table S4)

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In the rare disease space, Viking is developing VK0214, a novel, orally available, small molecule selective thyroid hormone receptor beta agonist for the potential treatment of X-linked adrenoleukodystrophy (X-ALD)