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Even though obesity and depression often occur together, clinical trials typically exclude people with severe depression
Interestingly, the influence on RAAS should also be considered in the clinical practice during the screening of suspected hyperaldosteronism due to the interfering regulation of sodium and water balance or mimicking the effects of beta-blockers (SGLT2-i)
The strengths of the study include its robust design and innovative methodology
In non-diabetic models, it induces endothelial injury via NOX2-dependent oxidative stress, increasing NF-B levels and vascular inflammation/early atherosclerosis (Huang, 2023)
