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Given the short half-life, twice-daily dosing provides additional exposure compared to once-daily protocols at the same total dose

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This allows for a personalized approach that prioritizes comfort, mobility, and overall function while addressing the challenges associated with spinal stenosis

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The typical pattern is to taper retatrutide down, keep cagrilintide at maintenance (1.7-2.4 mg/week), then resume retatrutide after a 4-8 week washout