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Consistent with the effects of GCGR in increasing lipolysis and thermogenesis besides elevating blood glucose levels, preclinical studies have found that peptide 20 improved energy metabolism and hepatic lipid handling without exacerbating preexisting hyperglycemia 22
Immunol Today (1999) 20:36775
L., DiVasta, A
Tirzepatide became the first dual GLP/GLP-1 receptor agonist to gain FDA approval for treating T2DM in 2022 and obesity in 2023 [ Table 2 ]
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