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Nevertheless, in a network meta-analysis comparing short-acting and long-acting GLP-1RAs when used in conjunction with basal insulin, long-acting GLP-1RAs resulted in significantly greater reductions in glycated hemoglobin (HbA1c), fasting plasma glucose, and body weight compared to short-acting GLP-1RAs, with better gastrointestinal tolerability [15]

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Anticipated retatrutide uses Obesity In the phase 2 trial of retatrutide published in the New England Journal of Medicine (NEJM), a group of 338 adults with obesity were randomly given either a placebo or one of four different doses of retatrutide: 1 mg, 4 mg, 8 mg, or 12 mg