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10.3748/wjg.v24.i48.5462 30 DuplancicB.StambolijaV.HoljevacJ.ZembaM.BalenovicI.DrmicD.et al (2014)

Keep Wegovy pens in their original carton to protect them from extreme temperatures and direct sunlight

Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations

It also works through a unique amylin-based pathway, which may help preserve lean muscle mass during weight loss

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However, it is noteworthy that 20% of patients treated with the 2.4 mg dose of pemvidutide discontinued treatment due to adverse events, with nausea and vomiting being the most common AEs